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The gut microbiota and its metabolites play a pivotal role in high-altitude adaptation by modulating the host immune system through multiple mechanisms ( 3.2.1 Mitigation of oxidative stress Certain gut microbiota and their metabolites enhance the defense of the gut mucosal barrier by alleviating excessive oxidative stress

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Peroxynitrite may also react with various amino acids in the peptide chain, thereby altering protein structure and subsequently, protein function

doi: 10.2147/NDT.S199746, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 66.Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N

Int J Child Neuropsychiatry 2005