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With respect to desensitization, all those data support the idea that agonists are able to promote a different regulation of OR as demonstrated for other GPCR such as the histamine H2 receptors (Alonso et al., 2014)

doi: 10.5021/ad.2013.25.2.218 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Kim YM, Cho SE, Kim SC, Jang HJ, Seo YK

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This is a lyophilized powder vial intended for research use this is not a capsule or oral supplement