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Thus, the results indicate that polymorphisms in TNFA (TNF-), TNFRSF1A (TNFR1) and TNFAIP3 (A20), which upregulate TNF- signaling, were associated with beneficial response to anti-TNF therapy among patients with IBD

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These were prolonged QTc intervals [89], gastric lesions, and lower esophageal sphincter and pyloric sphincter dysfunction induced by dopamine receptor antagonists [68,92,165,172], as well as gastric lesions induced by combined application of dopamine receptor antagonist and reserpine [166]

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This interaction with the pineal gland not only improves sleep quality but also has broader implications for hormonal balance and overall well-being