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Alonso, F., Kirkpatrick, C

The authors proposed that L-carnitine regulates the PTEN/Akt/mTOR signaling pathway, and enhances axonal plasticity while concurrently ameliorating oxidative stress and increasing oligodendrocyte myelination of axons and suggested that this attenuated cognitive impairment after chronic hypoperfusion [86] However, the increased CPT I and CPT II protein levels in L-carnitine treated rats may also have protected myelin after chronic hypoperfusion

It decreases insulin resistance and oxidative stress and improves immune function

PGC-1 activity is modulated by post-translational modifications such as phosphorylation, acetylation, and methylation, which can either enhance or inhibit its function

Psychoneuroendocrinology 43 , 2029 (2014)