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In contrast, studies have demonstrated that the inhibition of glutamine metabolism in cancer cells using the DON precursor drug DRP-104 results in an augmentation of the number of NK and NK T-cells within the immune microenvironment, thereby enhancing anti-tumor immunity [121]

Compound 119 was converted into epoxide R -87, which was allowed to react with the Grignard reagent to give secondary alcohol 89

Cell 177(5):1262-1279 e25

A 30Gx13 mm needle was used for the 0.025 mls intradermal injections to create micro-papules with a 1 cm distance between the injection sites