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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Reiter R.J., Sharma R., Ma Q., Rorsales-Corral S., de Almeida Chuffa L.G

BPC-157 and KPV are two of the most discussed peptides for gut lining integrity and intestinal barrier support

& Cocco, E

Stuart KA, Riordan SM, Lidder S, Crostella L, Williams R, Skouteris GG

It acts as a dual agonist at amylin receptors (AMY1R, AMY2R, AMY3R, formed by calcitonin receptor heterodimerized with RAMP1-3) and calcitonin receptors, with structural modifications (e.g., N-terminal fatty acid acylation, proline substitutions) preventing fibril formation, enhancing stability, and enabling once-weekly dosing via albumin binding for prolonged circulation