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Using receiver operating characteristics (ROC) curve analysis, the sensitivity, specificity, and the area under curve of -GluCys, a precursor of GSH, and D-lactate, a terminal metabolite of methylglyoxal, were 88.00%, 81.48%, and 0.8874, and 88.00%, 77.78%, and 0.8415, respectively

Key points The recombinant therapeutic protein degradation in CHO cell systems is reviewed