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Warner, J

4,5 The tight gap allows only passive diffusion of lipid-soluble drugs at a molecular weight lower than 400-600 Da

& Frost, J

4.4.2 Phytochemicals and nutraceuticals with ROS-modulating capacity Many plant-derived compounds modulate endogenous defenses (e.g., NRF2 activation, NF-B suppression) rather than merely scavenging radicals

Finally, the scope and design of the FIH trial and subsequent studies (e.g., treatment duration) must be considered in order to design appropriate pivotal preclinical studies that will both enable the planned clinical studies and adequately inform of potential safety risks for the intended patient population or healthy volunteers
