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Furthermore, ajoene, a garlic by-product, demonstrated antioxidant properties in hepatic steatosis induced by a high-fat diet (HFD) through stimulation of AMPK signaling [195]

In contrast, the NEH2 domain mediates interaction with Keap1, a cytoplastic repressor that facilitates NRF2 ubiquitination and proteasomal degradation under basal conditions (Tong et al., 2006)

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With the sum of ISMTs corresponding to roughly 30% of the ibrutinib-related material it was shown that ibrutinib metabolism through the thio-metabolism with glutathione plays a prominent role, especially when CYP3A4 is inhibited

10.1128/mBio.00003-14 75 WagenerJ