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In breast cancer, CHAC1 overexpression promotes both proliferation and migration, while in ovarian cancer, its impact is primarily restricted to cell migration, with minimal effect on proliferation ( TP53, encoded by the TP53 gene and mutated in over 50% of human cancers, is essential for cell-cycle regulation and the induction of programmed cell death

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Rare cases of selenium toxicity from these nuts have been documented even with as few as 45 nuts per day over time

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