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In addition, recent studies have shown that pentadecanoylcarnitine (C15-carnitine) has a wide range of anti-inflammatory activities in a variety of diseases and has pleiotropic activities related to supporting physical and mental health, which also differs from the general knowledge of LCACs [61]

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Several in vitro and in vivo studies have alluded to possible mechanisms that contribute to ZDV-induced myopathy through the impairment of skeletal muscle mitochondria

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For example, a meta-analysis of 21 randomized, double-blind, placebo-controlled trials reported that 1.53 g/d of ALCAR significantly improved cognitive function assessed by a variety of methods in older adults with mild cognitive impairment or early Alzheimers disease [23]