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In principle, this can be mitigated in the application of single-voxel MRS, as once the voxel has been planned, the reference voltage or flip angles of the RF pulses can be adjusted so that the desired flip angle is achieved within the voxel

This finding thus underscores that periodontal inflammation is not merely an isolated oral condition but a potent driver of distal tissue damage and systemic comorbidity progression through immunometabolic reprogramming

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doi: 10.1016/s0022-510x(00)00421-4