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Therefore, when CERK is downregulated or inhibited, MMP increases and VDAC modulation occur, sensitizing NSCLC cells with oncogenic KRAS to CDDP [179]

I left my reconstituted vial out at room temperature for a few hours

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Transferrin receptor 1 (TFR1) mediates the uptake of Fe + , which is followed by the reduction of ferrous iron in acidic endosomes in response to prostate six transmembrane epithelial antigen 3 (STEAP3), which in turn passes through the divalent metal transporter protein 1 (DMT1) or enters the cytoplasmic pool of unstable iron that stores reactive iron (LIP) ( + reacts with hydrogen peroxide (H 2 O 2 ) via the Fenton reaction to produce ROS (mainly highly reactive hydroxyl radicals), which triggers lipid peroxidation and membrane damage, inducing ferroptosis