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These phenomena may reflect the immunosuppressive effects of pregnancy

As an exercise mimetic, it engages metabolic pathways normally activated by physical training

Notably, the functions of these modifying enzymes are highly context-dependent: for example, G9a can enhance pro-inflammatory gene expression through promoting H3K9me2 modification, driving M1 polarization (125)

These have been shown in models of muscle injury, tendon degeneration, and experimental colitis
