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Small real-world series also suggest that reduced-frequency dosing can hold a plateau

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Modulation Enhances VEGFR2 expression and downstream angiogenesis : BPC-157 induces rapid angiogenesis in granulation tissue via VEGFR2-associated mechanisms, promoting organized capillary formation and increased vascular density in wound regions 1-3

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However, frequent dosing of senolytics may increase the risk of adverse effects, making it essential to find the right balance between efficacy and safety.36 Emerging clinical and preclinical evidence suggests that intermittent senolytic dosing may reduce the risk of cumulative toxicity, including thrombocytopenia observed with agents such as navitoclax, while preserving efficacy.36 Continuous dosing, while potentially providing sustained clearance, increases exposure-related risks

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