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The colony was maintained as a mixed stock of homozygotes (UAS- Coeae6g / UAS- Coeae6g ) and heterozygotes (UAS- Coeae6g/+ ) but enriched with fluorescent progeny in each generation

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Exercise remains the dominant determinant of improvements in adiposity, insulin sensitivity, and functional capacity, while vitamin D appears to optimize the biochemical and cellular environment that supports these adaptations, particularly in individuals with deficiency