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10.1038/nature22379

Mutant forms and-syn aggregates cause mitochondrial dysfunction, activate inflammatory pathways, and ultimately cause neurodegeneration [23]

Eliminates toxins

Likewise, reduction of intracellular pH affects the maintenance of a pH gradient across the cell membrane and provokes loss of energy generation by bacterial metabolism such as respiratory chain (where reduced NADH dehydrogenase, succinic acid dehydrogenase, and reduced ubiquinone cytochrome-c oxidoreductase are inhibited) [18,21-24] and anaerobic glycolysis (which inhibits hexokinase) [6,25]