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A direct link between microbiota and skeletal muscle function has been highlighted by treating mice with broad-spectrum antibiotics, which results in reduced muscle endurance and increased fatigue, with no changes in muscle mass or composition, that were restored after natural bacterial repopulation (Nay et al., 2019)

The effect of this synergistic treatment is ASS-dependent, and the activity of the enzymes mentioned above can be restored by transfection of ASS, eliminating the sensitivity of tumor cells to ADI-PEG20 combined with 5-FU treatment

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