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Overall, therapeutic interventions targeting amino acid metabolism may provide novel biomarkers and treatment strategies for autoimmune-related diseases, but their clinical translation still depends on higher-resolution human validation and mechanism-oriented precision studies

In the study, researchers added a small dose of copper to animal ALS models receiving zinc and found that the copper prevented early death associated with high doses of zinc (Ermilova 2005)

In the context of senescence, PD-1 and PD-L1 are overexpressed in several in vitro models induced by drugs or related to normal aging phenotype 45

For example, it could disrupt the recruitment of certain protein partners to the receptor complex, affect PTMs crucial for signaling, or, similar to BAK1-5 protein, stabilize the PEPR1-BAK1 complex at the PM (Schwessinger et al., 2011)

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