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Administration is by deep intramuscular injection into the neck area

Tendon and Ligament Repair Moderate to Strong Evidence Evidence Rating: Moderate-Strong (Several animal studies, some independent replication) Research support for musculoskeletal healing is substantial: Achilles tendon injuries Ligament damage (MCL, ACL) Rotator cuff healing General tendinopathy Surgical repair enhancement The FAK-paxillin mechanism and VEGF upregulation provide clear biological rationale for these effects

Scientific literature has also explored AOD9604 in relation to cardiovascular risk factors, hypercholesterolemia, and broader features of metabolic syndrome, in addition to its central role in cartilage and fat-metabolism research

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Another significant metformin side effect: vitamin B12 deficiency