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Vitiligo is an autoimmune skin disease in which melanocytes are destroyed by autoreactive CD8 + T cells, resulting in cutaneous leukoplakia

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Hypermethylation of the promoter regions of tumor suppressor genes correlates with transcriptional silencing and disease progression [375]

The figure shows robust expression of ZO-1 in epithelial enterocytes of small intestinal organoids (which is diminished under CARD9-inhibited conditions)

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