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This would presumably rely on its spirosuccinimide moiety, which bears resemblance to both the glutarimide motif present in thalidomide analogs and the asparagine cyclic imide modification proposed to be a natural degron recognized by CRBN 38,39,40

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Front Pharmacol 15:1516650 Jiang Y et al (2024) Endocrine and metabolic factors and the risk of idiopathic pulmonary fibrosis: a Mendelian randomization study

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doi: 10.1111/acel.12888 24 CotelliM.CalabriaM.ManentiR.RosiniS.ZanettiO.CappaS

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Randomized Phase II Trial of Two Schedules of Decitabine As Frontline Therapy in Elderly Patients with Acute Myeloid Leukemia Ineligible for Standard Cytotoxic Induction Regimens

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