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PMID 15987694

Aside from compromised cognition 47 , poor muscle function 48 and insulin resistance 49 , aging is associated with reduced locomotor activity to novel environment 47,50 and increased alveolar size in the lung 51

In contrast, chronic Salmonella typhimurium infection is more severe in transgenic mice with increased intestinal permeability, suggesting that barrier defects ultimately result in enhanced disease progression despite the activation of protective mucosal immunity (32, 33)

Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1

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