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Both substances 1) restrain NLRP3 activation through blockage of mitochondrial ROS generation, and 2) dose-dependently attenuate IL-1-release in models of LPS-primed bone marrow-derived macrophages (BMDMs)

Discussion 1) The results of the study conducted by Richie et al demonstrated that oral glutathione (GSH) supplementation can effectively increase body compartment stores of GSH in healthy adults

Cell 181:223227

Materials and methods Post-mortem brain samples Frozen post-mortem tissues were obtained from the NICHD Brain and Tissue Bank for Developmental Disorders at the University of Maryland, Baltimore, MD, USA, and from the Autism Tissue Program at the Harvard Brain Tissue Resource Center, Belmont, MA, USA

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