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ALCAR and the Blood-Brain Barrier

Modification of apoB lipoproteins via oxidation and glycation enhances their uptake through a number of receptors not down-regulated by cholesterol including CD36, scavenger receptor A, and lectin-like receptor family (see details below) (Figure 2) (46,47)

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The current transport model for the NPC system postulates that NPC2 binds sterols in the lumen and loads them into the NTD, which transfers the sterol to a tunnel that is formed by the middle-luminal domain and C-terminal domain of hNPC1 and NCR1, respectively (1, 27, 33, 34)