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Lifelong treatment with antioxidants has been recommended in an attempt to prevent morbidity and mortality associated with the disorder

Excessive VEGF activity promotes tumor growth, invasion, and metastasis, while insufficient signaling contributes to impaired wound healing and ischemic diseases

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A (served as the control), B (received 3 mg/kg CdCL2), C (received 100 mg/kg PREOG), D (received 200 mg/kg PREOG), E (received 100 mg/kg PREOG+3 mg/kg CdCL2) and F (received 200 mg/kg PREOG+3 mg/kg CdCL2) treatment continued to postnatal day 29 before weaning