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L-2 hydroxyglutaric aciduria L-2hydroxyglutaric aciduria (L2HGA) is a rare, progressive, autosomal recessive disorder of organic acid metabolism

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For example, the widely used chemotherapeutic drugs doxorubicin (DOX), cisplatin (CIS), Fluorouracil (5-FU), methotrexate (MTX) and tamoxifen (TAM) have high antitumor efficacy, meanwhile with serious damage to multiple organs (e.g., cardiomyopathy, acute renal failure, acute toxic leukoencephalopathy, hepatic steatosis and testicular toxicity) (154158)

Sikder et al., 2018

Lipo-C supports metabolism but doesn't permanently change it