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M.Van OpdenboschN.Van GorpH.ParthoensE.LamkanfiM

5 Evidence indicates that patients with TED produce autoantibodies that stimulate this receptor complex, causing hyperactivation of orbital fibroblasts and immune cells which mediate the disease process in susceptible individuals

Gut permeability and its clinical relevance in schizophrenia

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Together, these results suggest that leptin-mediated LepR dimerization is primarily driven by the aromatic and polar contacts formed by leptin residues Tyr119 and S120 at site 3a, with the receptor-induced conformational change of the leptin AB loop playing a secondary role to further stabilize the LepR dimer and enable maximal STAT3 activation