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However, accumulating evidence suggests that all LDH isoforms retain the inherent capacity to mediate pyruvate-to-lactate conversion accompanied by NAD+ regeneration, and that LDHA and LDHB can functionally compensate for each other under metabolic stress (44,45)

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This improved ability to control intracellular mycobacteria could be through the improved redox homeostasis in the cell and possibly through modulation of cytokines that result in a more effective immune response against these infections

What do we learn from cell culture and in vivo studies