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Nevertheless, in 2003 a systematic review concluded there was insufficient evidence to recommend a clinical use, although a meta-analysis in the same year showed a significant advantage for ALC for clinical scales and psychometric tests

[DOI] [PubMed] [Google Scholar] 130.Roep B.O., Schipper R., Verduyn W., Bruining G.J., Schreuder G.M., de Vries R.R

10.1093/ilar.52.1.66 ILAR J

By promoting the conversion of acetyl-CoA to acetylcarnitine, carnitine reduces the ratio of acetyl-CoA/CoA, thereby reducing the activity of PDH kinase and restoring the activity of PDH, allowing more pyruvate to enter the mitochondria for oxidation to produce energy [288]

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