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In comparison to all other forms of inhaled oxidants, CS may be one of the most prevalent and preventable oxidant exposures, with nearly 1 billion smokers worldwide

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Key gaps include limited direct cytotoxicity data for the 1723 fragment across diverse cell types, limited blood-compatibility data, limited formal immunogenicity data for the fragment, limited toxicokinetic information, limited local-tolerance information, limited reproductive and developmental toxicology data, limited genotoxicity data, and the absence of broadly applicable GLP-compliant repeat-dose toxicology packages for marketplace research materials