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For example, complete loss of PGRN leads to Neuronal Ceroid Lipofuscinosis 67,68 , a neurodegenerative disease characterized by lysosomal accumulation of lipofuscin, a lipid-protein aggregate

Plasma omega-3 fatty acids and incident diabetes in older adults

177 QuadratoG.NguyenT.MacoskoE

The toxicity of dopamine has been demonstrated in a variety of in vitro models, and previous experiments have demonstrated the selective toxicity of dopamine in vivo after exogenous dopamine injection into the striatum, resulting in the selective toxicity of dopamine receptor nerve terminals and the loss of dopaminergic neurons in the substantia nigra [202,203]

