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Ex vivo studies demonstrate that berberine and its eight analogs inhibit cancer cell viability in a canine mammary carcinoma cell line and transgenic zebrafish models through apoptosis induction, while zebrafish embryo toxicity experiments are conducted to assess the in vivo safety of berberine [198, 199]

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Agranulocytosis is the most serious complication of antithyroid drug therapy and is estimated to occur in 0.1 to 0.5 percent of patients treated with these drugs [7]

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Targeting the PPP for cancer therapy is challenging