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Mechanistically, we elucidated that the improved anti-PC efficacy of co-delivery nanovesicles was attributed to the better ability to decrease the levels of cytidine deaminase (CDA), which can degrade GEM to its inactive metabolite by inducing the oxidative stress (HO-1) 35 , and the increased expression of apoptosis (cleaved caspase-3

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-20C, 1 month (sealed storage, away from moisture) Biological Activity In Vivo in vivo , and decreases heart and respiration rate as well