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Deficiency of GPx results in direct tissue damage and activation of age-related NF-B inflammatory pathways [57]

Depletion of bioavailable nitric oxide in the vasculature by excess oxidants causes endothelial dysfunction, which is characterized by a decrease in endothelium-dependent vasodilation while retaining the ability of vascular smooth muscle cells to vasodilate in response to nitric oxide donors, such as sodium nitroprusside [53]

Glutathione helps reduce oxidative damage to skin cells and has been shown to influence melanin production, which contributes to a more even skin tone

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