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Oral Pathology Oral Radiology 135 (1), 7995

Figure 2 4.2 Synaptic plasticity and neurotransmission PSD-95, a protein in neurons with a PDZ domain, has been observed to promote the maturation of glutamatergic synapses in hippocampal neurons when its expression is increased ( Modulation of the neurotransmitter system is a key process for maintaining the normal function of the nervous system ( 4.3 Apoptosis and autophagy regulation Apoptosis is an integral part of organism's development, tissue remodeling, and disease treatment ( Autophagy is a process of intracellular degradation and recycling of damaged or excess cellular components ( Omega-3 fatty acids, especially DHA, inhibit apoptosis by upregulating Bcl-2 and preventing Bax translocation, while EPA enhances autophagic flux by inhibiting the mTORC1 complex

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Furthermore, NMDAR activation-mediated calcium influx can trigger calpain activation

During the process of fish growth, any pressure condition will directly or indirectly cause oxidative stress, leading to the level of intracellular ROS related to oxidative stress increasing, causing destructive effects on lipids, proteins, and DNA (Martnez lvarez et al., 2005