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First, the gut microbiota could regulate metabolic processes in the human body through gut microbial metabolites as short-chain fatty acids, trimethylamine N-oxide, and bile acids, all of which have been associated with many CAD-related phenotype and can influence the course of cardiovascular disease (Wang and Zhao, 2018)

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We then regrouped the 112 fecal samples collected from the 56 subjects before and after carnitine supplementation, based on its corresponding status of TMAO producing capacity: 61 samples were grouped as low-TMAO producer (TMAO MAX 10 M) according to the OCCT results

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