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22nd Annual Pacific Symposium on Biocomputing 2017, Hawaii, USA, January 3-7, 2017 34

For evaluating individual metabolites, the number of effective tests (NEF) 90 was used to adjust for multiple comparisons as NEF has the advantage of accounting for the high correlation structure of the metabolomics data

The link is there but literature is unclear on whether TMAO is a bystander or a mediator (Janeiro et al