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Note that animals which are recumbent (downer cows or post-surgical patients) will have high CK activity (up to 10 x normal) from muscle injury or ischemia
In addition, an inflammatory response was also noted in 13% of these cases

Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation

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Altered levels of Bcl2 and p53 proteins in parietal cortex reflect deranged apoptotic regulation in autism