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For example, in breast cancer, paclitaxel inhibits the PI3K/AKT signaling pathway, upregulates cleaved caspase-3 and Bax expression, and downregulates Bcl-2 expression, and the combination of the AKT inhibitor Capivasertib with paclitaxel significantly prolongs the progression-free survival and overall survival of breast cancer patients (Li et al., 2020)

[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Macabrey D, Longchamp A, MacArthur MR, et al
