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Some studies indicate people with obesity have low vitamin B12 levels

Conditions like pernicious anaemia (an autoimmune condition affecting a protein called intrinsic factor vital for B12 absorption), stomach issues (such as from reduced stomach acid or certain medications like proton pump inhibitors), intestinal disorders (like Crohns disease or coeliac disease), or even surgical removal of parts of the small intestine (e.g., gastric bypass surgery) can prevent proper absorption

Some users report flushing, similar to niacin, though this is less common with NR and NMN than with nicotinic acid

For this reason, B12 injections are often recommended as a preventive measure to help maintain cognitive health over time

It is formulated for severe neuropathic conditions and vitamin B12 deficiency