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Hashimoto's encephalopathy: A steroid-responsive disorder associated with high antithyroid antibody titers -- report of five cases

because rigorously controlled human safety data specific to the TB-500 fragment does not exist, its longer-term risk profile, including possible immune reactions, remains unknown Evidence snapshot: Evidence for TB-500 itself is preclinical, drawn mainly from cell-culture and animal studies (a 1999 rat wound-healing study and later rodent cardiac- and tendon-injury models), with a 2026 scoping review describing the musculoskeletal literature on thymosin beta-4 and TB-500 as sparse and largely preclinical

For comparison with other anti-aging approaches, see Epitalon vs NAD+ and Epitalon vs FOXO4-DRI

[PMC free article: PMC3226845] [PubMed: 21868017] 759

Kinesiol 10 (2), 170