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Role of AMPA receptor endocytosis in synaptic plasticity

Evidence Tier Framework Tier 1 FDA-approved therapy large randomized trials Tier 2 human trials demonstrating biological effect Tier 3 small human studies or limited clinical data Tier 4 animal models or anecdotal reports Stacking should generally involve: at least one Tier 1 therapy no more than one Tier 3 compound Stacks composed entirely of Tier 34 compounds should not be considered clinical protocols

The region of 1 that is solvent-exposed when in a binary complex with SMARCA2 BD forms extensive direct interactions with DCAF16, in addition to the covalent bond with C173

doi: 10.1080/14656566.2022.2108702, 8

18 In a multicenter clinical trial involving 1069 patients (682 children and 387 adults), four cases of hemolytic anemia were reported (subsequently, G6PD deficiency was diagnosed in one patient), and three patients were reported to have methemoglobinemia