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Biomed Pharmacother 111:802812

RMSF and solvent-accessible surface area (SASA) (Broz et al., 2024) analyses indicated that DON and ZINC03978829 interacts more closely with GLS, reducing the fluctuation of enzyme residues and apparent exposure

10.1016/j.injury.2021.08.019 43 ConnollyB

Currently, however, there is a severe lack of human clinical data to support these claims, and fewer than five human trials are indexed in major databases, most with small sample sizes or unclear methodologies

While inhibitors specific to TRIM RING domains have not yet been reported, the fact that small molecule inhibitors of the RING domains from other protein families exist (Valletti et al., 2019)