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This gene cluster includes a dihydrodiol dehydrogenase ( phtB) , a multi-component dioxygenase containing large ( phtAa ) and small (phtAb) subunits, a ferredoxin ( phtAc ) and a reductase ( phtAd ), apart from a decarboxylase ( phtC ) and an IcIR-type regulator ( phtR )

This pattern holds regardless of whether the person exercises or follows a strict diet after stopping the medication, suggesting that these medications alter biological set points rather than simply reducing appetite

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The six-month randomised trial that lifted body stores ran its headline arm at 1000mg a day

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