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These cytokines may influence central nervous system function through neuroinflammatory pathways and have been implicated in the pathophysiology of fatigue, mood disturbances, and altered pain perception

doi: 10.1002/arch.21777 59 HuXZhuMZhangXLiuBLiangZHuangLet al

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These studies should use mtDNA health as a primary endpoint (e.g., copy number, deletion load), alongside measures of immune function, inflammation, and clinical outcomes, to establish a direct link between improved mitochondrial function and patient health
