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Male SD rats were administered a single IM injection of blank solvent (excipient), and biological samples, including whole blood, plasma, urine, feces, and tissues, were collected for background control

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However, morphine's failure to trigger regulation of receptor signaling cannot be extended to all systems since several reports have shown that this drug causes arrestine recruitment, desensitization and endocytosis of mu (MORs) [3235] and delta (DORs) [35, 36] opioid receptors

A limited number of studies have reported increased systemic levels of claudins as a marker for impaired intestinal barrier function, e.g., increased serum claudin-5 in children with attention deficit hyperactivity disorder (67) and increased urinary claudin-3 in patients with active Crohn's disease which was associated with decreased claudin-3 staining in intestinal biopsies (68)