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Detection of mRNA and protein levels showed that KD or ketone bodies can improve mitochondrial biogenesis and bioenergetics through the peroxisome proliferator-activated receptor -coactivator-1 sirtuin 3 uncoupling proteins 2 axis, and uncoupling proteins upregulated by mitochondrial respiration can reduce the production of ROS and oxidative stress (129, 130)

The effect is especially large in more socially anxious individuals (Pause et al., Reference Pause, Adolph, Prehn-Kristensen and Ferstl2009), in whom there is also evidence for early processing bias towards anxious odour and increased allocation of neuronal resources (Pause et al., Reference Pause, Lbke, Laudien and Ferstl2010)

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