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Comparison of the cytoprotective potential of chelator SIH and prochelator BSIH The comparison of diverse Fe chelators revealed that although some protection can be a general property of Fe chelators, the lipophilic agents (L1, ICL-670A, SIH) have higher potential to exert neuroprotection, apparently due to the better access to intracellular labile Fe pool

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These discoveries imply that the robust connections between serum GGT and various cardiovascular risk factors or events may be explained by mechanisms linked to oxidative stress

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3.3 Increased neuronal excitability in DRG neurons DRG neurons express a variety of ion channels including, voltage-gated sodium channels (Na v ), voltage-gated potassium channels (K v ), voltage-gated calcium channels (Ca v ), chloride channels and transient receptor potential (TRP) channels