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Side effects from B12 supplementation are uncommon but may include: Mild gastrointestinal symptoms such as nausea or diarrhoea, typically with very high oral doses Headache or dizziness in some individuals Skin reactions (rash, itching) at injection sites when using intramuscular preparations Rare but serious allergic reactions, including anaphylaxis with injectable forms Hypokalaemia (low potassium) may occur during rapid correction of severe megaloblastic anaemia If you experience symptoms of a severe allergic reaction (difficulty breathing, severe rash, swelling of face or throat) after taking B12, seek immediate medical attention

Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of beta2-Adrenergic Receptors

The short answer is yes

J Biol Chem 270 : 2948329492 Rudman D et al

If you do experience flaking from using retinol, it may be that youre using a retinol product thats just too potent for your skin or youre applying the retinol product too often